The Value of Index of Microvascular Resistance Measured Before and Following Percutaneous Coronary Intervention in Predicting Perioperative Myocardial Infarction in Patients With Stable Coronary Artery Disease / 中国循环杂志

Objectives: This study was designed to assess whether measurement of the index of microvascular resistance (IMR) before and following percutaneous coronary intervention (PCI) could help identify patients who develop periprocedural myocardial infarction (PPMI). Methods: 54 patients with stable coronary artery disease undergoing elective PCI were divided into PPMI group and no-PPMI group. IMR and FFR was measured before and following percutaneous coronary intervention (PCI) with a pressure wire. Times of balloon inflation was also analyzed. hs-TnI at 24 h post PCI was measured. rPIMR value was calculated. Results: IMR obtained at pre-PCI and post-PCI as well as rPIMR were significantly higher in PPMI patients than in no-PPMI patients (22.02±2.92 vs 17.46±3.44, 25.86±3.04 vs 18.96±2.84, 1.22±0.21 vs 0.94±0.24, all P<0.05, respectively). Patients with PPMI more frequently underwent pre- and post-dilatation(70.8% vs 36.7%, 54.2% vs 23.3%, P<0.05), respectively, the number of balloon inflations was significantly higher in patients with PPMI than in no-PPMI patients (4.33±1.79 vs 3.20±1.63, P<0.05). The area under the ROC curve for predicting PPMI event by pre-PCI IMR was 0.941 (95%CI: 0.884-0.998, P<0.05), cut-off value was 19.91 (sensitivity: 95.8% and specificity: 77.0%). Multivariate logistic analysis showed that pre- and post-PCI IMR, rPIMR were positively correlated with PPMI (all P<0.05). Conclusions: Measuring IMR and rPIMR may allow prospective identification of patients at increased risk of PPMI.

Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus / 中国天然药物

Huanglian Wendan decoction (HLWDD) has been used for the treatment of symptom of "Re", one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigating the cerebral protective effects of HLWDD on diabetic encephalopathy (DE), one of the major diabetic complications. The effects of HLWDD and metformin were analyzed in the streptozocin (STZ) + high-glucose-fat (HGF) diet-induced DE rats by gastric intubation. In the present study, the effects of HLWDD on cognition deficits were investigated after 30-day intervention at two daily dose levels (3 and 6 g·kg). To explore the potential mechanisms underlying the effects of HLWDD, we detected the alterations of neuronal damages, inflammatory cytokines, and impaired insulin signaling pathway in hippocampus of the DE rats. Based on our results from the present study, we concluded that the protective effects of HLWDD against the cognitive deficits and neuronal damages through inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus of the DE rats.

The effects of 40 mg atorvastatin on serum lipids, inflammatory markers and clinical events in ACS patients post PCI / 中华心血管病杂志

<p><b>OBJECTIVE</b>To assess the safety and effects of 40 mg atorvastatin on serum lipids, inflammatory markers and clinical events in ACS patients post PCI.</p><p><b>METHODS</b>A total of 92 patients with ACS post successful PCI were randomly divided into atorvastatin 10 mg/d (group A) and atorvastatin 40 mg/d (group B) on top of the standard medical therapy. Blood were taken at baseline, 4, 12 and 24 weeks for serum alanine aminotransferase (ALT), lipids, high-sensitive C-reactive protein (hs-CRP) and matrix metalloprotease-9 (MMP-9) measurements. The major adverse cardiac events (MACE) were also observed.</p><p><b>RESULTS</b>There was no significant difference in medication withdrawn (2 vs. 3 cases) due to increased ALT (3 times higher than normal) and incidence of MACE (5 vs. 7 cases) between the groups. TC and LDL were significantly reduced in both groups 4 weeks and thereafter post medication compared to pre-treatment (P < 0.05) and the reduction was more significant in group B than that in group A at 24 weeks post medication (P < 0.05) while TG and HDL remained unchanged. hs-CRP was significantly reduced at 12 and 24 weeks in both groups compared to baseline and the reduction was more significant in group B than that in group A at 24 weeks. MMP-9 was significantly reduced in both groups 4 weeks and thereafter post medication compared to pre-treatment (P < 0.05) and the reduction was more significant in group B than that in group A at 12 weeks post medication (P < 0.05).</p><p><b>CONCLUSION</b>Both atorvastatin doses significantly reduced TC, LDL, hs-CRP and MMP-9 in ACS patients post PCI and the reduction was more significant in high dose atorvastatin group at 24 weeks while the MACE and drug withdraw rates were similar between the groups.</p>

The Influence of Thy-1.1 Stem Cell Transplantation on Neointimal Formation of Injured Artery / 中华高血压杂志

Objective To study the effect of Thy-1.1 stem cell transplantation on endothelial hyperplasia and restenosis.Methods Thirty 4-6 weeks male SD rats were sacrificed to obtain the Thy-1.1 stem cells.Carotid artery were injured by ballon in sixty female SD rat's were randomized to receive stem cell transplantation(5?10~6 Thy-1.1,n=30)or saline approach(n=30).About 5?10~6 Thy-1.1 stem cells were injected into the injured arter- y after carotid artery injury;while the control rats underwent carotid artery injury and was injected the same amount of saline.The animals were sacrificed,3,7,14,21 and 28 days after balloon denudation.The samples of carotid artery were harvested for pathological examination,RT-PCR and in situ hyhridzation(ISH)were used to detect the transplanted cells in the injured artery.Results The intimal thickness was thinner in stem cell transplantation group(I/M,Stem cell transplantation group:2.06?0.28 vs control group 2.42?0.19,P